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2 edition of characterisation of interleukin 7 - sulphated polysaccharide interactions found in the catalog.

characterisation of interleukin 7 - sulphated polysaccharide interactions

Moktar O. GueМЃlleМЃ

characterisation of interleukin 7 - sulphated polysaccharide interactions

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Published by University of Portsmouth in Portsmouth .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Portsmouth, 2002.

StatementMoktar O. Guéllé.
ID Numbers
Open LibraryOL19927248M

Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease endemic in the Republic of Tatarstan, Russia [].Puumala orthohantavirus (PUUV) is commonly isolated from human HFRS blood and tissue samples as well as bank voles captured in the region [].HFRS is characterized by kidney insufficiency and disturbed blood coagulation [3,4,5,6,7].Cited by: 2. Get this from a library! Modern trends in human leukemia IX: new results in clinical and biological research including pediatric oncology ; organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie, Wilsede, June , [Rolf Neth; . T1 - Inhibition of interleukin production in lipopolysaccharide- activated mouse macrophages by hpyericin, an active component of Hypericin perforatum. AU - Kang, B. Y. AU - Chung, S. W. AU - Kim, Tae Sung. PY - /7/9. Y1 - /7/9Cited by:


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characterisation of interleukin 7 - sulphated polysaccharide interactions by Moktar O. GueМЃlleМЃ Download PDF EPUB FB2

The characterisation of interleukin 7 - sulphated polysaccharide interactions. (Thesis) Guéllé MO. Publisher: University of Portsmouth [] Metadata Source: The British Library Type: Thesis. Abstract. No abstract supplied.

Menu. Formats. Abstract Author: Guéllé Mo. The characterisation of interleukin 7 - sulphated polysaccharide interactions Author: GueÌ lleÌ, Moktar O. Two cytokines, Fms-like tyrosine kinase 3L (Flt3L, also known as Flk2L) and interleukin-7 (IL-7) contribute to murine B lymphopoeisis early and later in life, respectively.

IL-7 is essential for production of human B cells from adult bone marrow and the dependency of B lymphopoiesis on IL-7 becomes progressively more profound during ontogeny (11, 12).Cited by: 2.

In the present study, we employed surface plasmon resonance (SPR) spectroscopy to dissect the binding interactions between GAGs and murine and human forms of characterisation of interleukin 7 - sulphated polysaccharide interactions book (IL-7).

The subpopulation of dendritic cells (DCs) and regulatory T cells (Tregs) from PHPS-treated mice splenocytes were also measured by flow cytometry.

Consistent with previous reports, we showed that PHPS increased the phagocytosis of RAW macrophages, and enhanced the secretion of interleukin (IL)-6, IL and tumor necrosis factor-α (TNF-α).Cited by: The interaction of hIL-7 to heparin displayed a fold and fold faster on- and off-rates compared with the mIL-7/heparin interaction.

The significantly faster kinetic rates for the hIL-7/heparin interaction translate into a fold higher binding affinity than the mIL-7/heparin by:   The purified E. coli-derived interleukin 2 is a monomeric protein of Mr 15 with a sedimentation velocity of Characterisation of interleukin 7 - sulphated polysaccharide interactions book.

The amino acid composition of the protein and isoelectric point () are consistent with that part of the translated DNA sequence Cited by: Furthermore, several biological activities of sulphated polysaccharides obtained from red algae, such as antioxidant [7], anti-inflammatory and antinociceptive [8], anticoagulant [9], anticancer.

Molecules that bind recombinant interleukin 1 (rIL-1)β and rIL-1 receptor antagonist (rIL-1ra) with characterisation of interleukin 7 - sulphated polysaccharide interactions book affinity were detected in sera of healthy individuals.

rIL-1β bound with dissociation constants in the nanomolar range, and the serum binding capacity was 40–50 ng/ml.

rIL-1ra bound with 30 times higher affinity, and the serum binding capacity was ng/ml. Rabbit antibodies against Cited by: Interleukin-6 (IL-6) is an example of such a multifunctional cytokine and exerts multiple effects on the immune, hematopoietic and nervous system in a finely regulated interaction with its two receptors: interleukin-6 receptor (IL-6R) and glycoprotein (gp), the component critical for Cited by: 6.

Appasamy, P.,Biological and clinical implications of interleukin-7 and lymphopoiesis, Cytokines Cell Mol Then – Google ScholarCited by: 9. [Frontiers in Bioscience, 1, d] MOLECULAR AND CELLULAR BIOLOGY OF INTERLEUKIN-6 AND ITS RECEPTOR Evan T.

Keller1,2,3,4, Jon Wanagat1, W.B. Ershler1,3 1Glennan Center for Geriatrics and Gerontology, Departments of 2Pathology File Size: KB. Several immune cytokines, including interleukin-2 (IL-2), interleukin-7 (IL-7) and gamma interferon (INF-γ), have been shown to interact with the sulphated polysaccharides heparin and heparan.

Abstract. Bacterial infections as well as immunological diseases result in activation of various endogenous mediators including cytokines ().One of these cytokines is interleukin-8 (IL-8) which attracts neutrophils, basophils characterisation of interleukin 7 - sulphated polysaccharide interactions book T-cells, induces adherence to vascular endothelium and extravasation into tissue spaces ().It has been evidenced that the levels of IL-8 in body fluids are elevated Author: Paweł P.

Jagodzinski, Wiesław H. Trzeciak. The binding of IL-8 to sulfated glycosaminoglycans (GAGs) is a crucial step for the regulation of cell adhesion, migration and inflammation.

Due to the great structural diversity of GAGs, a number of important questions concerning the matrix interaction of IL-8 remain by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

In the present study we characterised these interactions using a series of chemically modified heparins as competitive inhibitors. Human interleukin and p40 homodimer show indistinguishable binding profiles with a panel of heparin derivatives, but that of murine interleukin is by: 3. Sulfated polysaccharides are capable of binding with proteins at several levels of specificity.

As highly acidic macromolecules, they can bind non-specifically to any basic patch on a protein surface at low ionic strength, and such interactions are not likely to be physiologically significant.

On. Growth factors are potent stimulators or inhibitors of satellite cell proliferation and differentiation. The proper function of some cytokines and growth factors requires an interaction with the cell membrane-associated proteoglycans to enhance the affinity to bind to their primary receptors to initiate downstream signal by: 1.

Interleukin 7 is produced by murine and human keratinocytes. This article has been cited by other articles in PMC. Abstract. Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well.

The structural characterization, antioxidant activity and protective effect against H2O2-induced injury RAW cells of a new polysaccharide (MP1) isolated from Lepidium meyenii Walp.

were. Disease description A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5.

Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. A Biosensor Study Indicating That Entropy, Electrostatics, and Receptor Glycosylation Drive the Binding Interaction between Interleukin-7 and Its Receptor Scott T.

PhD Thesis – List of Publications Nayyar Ahmed vii Ahmed N & Suphioglu C,‘Discovering the effects of omega-6 fatty acids on allergy using a HEK-Blue cell line’, Allergy, vol.

69, p. Ahmed N, Ramsbottom K, Carr S & Suphioglu C,‘Identification and characterization of IL-4 and IL-4 receptor as novel intervention targets for allergy treatment’, Allergy, : Nayyar Ahmed.

Receptor for interleukin Also acts as a receptor for thymic stromal lymphopoietin (TSLP). The stromal reaction is a characteristic feature of numerous solid tumours, independent of their malignant capacity.

Tumour stroma and tumour fibrotic tissue contain proteoglycans and glycosaminoglycans, often in higher proportion than normal, surrounding tissue [19].Cited by: Akira, S., Hirano, T., Taga, T., and Kishimoto, T.,Expression of interleukin-2 receptor gamma chain on human neutrophils, FASEB J.

– PubMed Google Cited by: 4. Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological functions that include regulation of immune cell proliferation and by: University, UK, with the title: ‘The interactions of immune cytokines with sulphated polysaccharides.

SCIENTIFIC POSITIONS 06 February -present: Lecturer, Division of Biochemistry, Faculty of Medicine, University of Patras. 19 July - 01 February Research Scientist (grade 8, point 7), Sir William Dunn School of.

Pharmaceutical compositions useful for the treatment of interleukin-1 mediated diseases are provided. The pharmaceutical compositions contain interleukin-1 inhibitors and protein stabilizers such as non-ionic surfactants and viscosity enhancers.

The addition of a non-ionic surfactant or a viscosity enhancer is effective in stabilizing interleukin-1 inhibitors and, therefore, in pro-longing the Cited by: Cisplatin (cis-diamminedichloroplatinum) is widely used for the treatment of solid malignancies; however, the development of chemoresistance hinders the success of this chemotherapeutic in the clinic.

This study provides novel insights into the molecular and phenotypic changes in an isogenic oesophageal adenocarcinoma (OAC) model of acquired cisplatin resistance. Key differences that could be Cited by: 2. Mature T cells respond to IL-7 and Con A, but not to IL-7 alone. Antibodies against IL-2 affect its activity, suggesting that it functions through IL-2 production.

Human natural IL-7 is 25 kDa glycoprotein that has 6 cysteine residues which are important for biological activity. Human and mouse IL-7 have 60% amino acid sequence homology. INTRODUCTION. Interleukin-4 (IL-4) 1 and interleukin (IL) are structurally and functionally related cytokines that share common receptor components (1–3).IL-4 and IL exhibit approximately 30% amino acid sequence similarity and are encoded by genes with a similar intron/exon structure that are closely linked on human chromosome 5 and mouse chromosome   Recently, interleukin-6 (IL-6) 1 has attracted special attention because a strong correlation has been found between serum and/or local levels of IL-6 and bone resorption in various diseases.

IL-6 is a pleiotropic cytokine with multiple and diverse effects on various cell types (2, 4, 6, 7).Cited by: Interleukin-7 is a lymphoid cell growth factor which affects pre-B, pro-B and early T cells. It supports the growth of early B cells and is mitogenic for thymocytes and co-mitogenic with PHA and Con A.

IL-7 stimulates the proliferation of CD4/CD8 cells. Human and mouse IL-7 have 60% amino acid sequence identity. Physical form. Ensembl ENSG ENSMUSG UniProt Q Q RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr 6: – Mb Chr 1: – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse InterleukinA is a protein that in humans is encoded by the IL17A gene.

Contents 1 Function 2 Aliases: IL17A, CTLA8, IL, ILA, IL17, CTLA. Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored.

The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial Cited by: The biological role and potential therapeutic application of interleukin 7 Agnieszka Krawczenko1, Claudine Kieda2 and Danuta Duś1 1 Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland 2 Cell Recognition Group, CBM, UPR CNRS, Orléans, France Source of support: by the State Committee for Scientific Research (KBN, Poland).

A number of cytokines have shown beneficial effects in preclinical animal models of cancer and chronic inflammatory diseases. However, cytokine treatment is often associated with severe side effects, which prevent the administration of clinically relevant doses in humans.

Immunocytokines are a novel class of biopharmaceuticals, consisting of a cytokine moiety fused to monoclonal antibodies or.

Function: Receptor for interleukin Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Gene References into Functions: No significant association between the IL7RA C/T (rs) and IL12B AC (rs) gene polymorphisms and multiple sclerosis susceptibility was observed PMID: ; Increased signal transduction and proliferation in response to IL-7 was found in 'TT Uniprot No.: P.

Interleukin 7 pdf is a critical cytokine that plays a fundamental role in B- and T-cell development and in acute lymphoblastic pdf (ALL). Its receptor (IL7R) is a transmembrane heterodimer formed by the IL7Rα and the IL2Rγ chain (γc).

The IL7R signals through the JAK/STAT pathway. Loss-of-function mutations and some polymorphisms of the IL7Rα were associated to Author: Lívia Weijenborg Campos, Leonardo Granato Pissinato, José Andrés Yunes. The IL receptor complex also consists of at least three subunits.

It shares use of download pdf common β and γ chains of the IL-2R complex but contains an α subunit that is distinct from IL-2Rα (3, 7, 8). Similar to the IL-2R complex, interaction of IL with both the β and γ subunits is necessary for initiation of signaling.Interleukin 7 receptor, IL7R, is expressed exclusively ebook cells of the lymphoid lineage and its expression is crucial for development and maintenance of T cells.

While transcriptional regulation of IL7R expression has been widely studied, its posttranscriptional regulation has .